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#Free clinical trials to stop opiates in dayton trial

Up to 122 patients (61 in each randomized arm)

All the patients are expected to complete the 2-weeks inpatientĭetoxification programme at the NAMS ward. Patients will be receiving 10 days of Lofexidine plus Diazepam placebo or Diazepam Study Design: This is a randomized, double-blind (double-dummy design) phase IV clinical

#Free clinical trials to stop opiates in dayton trial

Lofexidine for Inpatient Opiate Detox in SingaporeĪ Double-blind Randomised Controlled Clinical Trial of Lofexidine Versus Diazepam in the Management of the Opioid Withdrawal Syndrome During Inpatient Detoxification in Singapore

To evaluate differences in emotional/psychological symptoms.

To evaluate differences in time to drop-out (length of stay on the ward).

To evaluate differences in craving on the Visual Analogue Scale.

To evaluate differences in pupil sizes.

To evaluate differences in SOWS (Short Opiate Withdrawal Scale).

To evaluate differences in OOWS (Objective Opiate Withdrawal Scale) Opiate Dependent Patients Who Are Undergoing Inpatient Detoxification in Singapore The management of the opiate withdrawal syndrome during inpatient detoxification. Of the study is to establish an alternative medication to reduce opiate withdrawal symptomsįor use in Singapore by evaluating the clinical efficacy of Lofexidine versus Diazepam in Initiated discharge) because of the severity of unpleasant withdrawal symptoms. Opiate patients undergoing inpatient detoxification leave prematurely (i.e.

Reduce the physical and psychological craving for opioids which can trigger relapse. Is highly addictive and widely abused among heroin users and pharmacologically, does not The standard treatment is one week of detoxification assisted withĭiazepam and symptomatic treatment followed by one week of rehabilitation.

In Singapore, opiate substitution medication e.g.